Abstract: In this paper, we try to systematically study how to perform doctor recommendation in medical social networks (MSNs). Specifically, employing a real-world medical dataset as the source in our work, we propose iBole, a novel hybrid multi-layer architecture, to solve this problem. First, we mine doctor-patient relationships/ties via a time-constraint probability factor graph model (TPFG). Second, we extract network features for ranking nodes. Finally, we propose RWRModel, a doctor recommendation model via the random walk with restart method. Our real-world experiments validate the effectiveness of the proposed methods. Experimental results show that we obtain good accuracy in mining doctor-patient relationships from the network, and the doctor recommendation performance is better than that of the baseline algorithms:traditional Ranking SVM (RSVM) and the individual doctor recommendation model (IDR-Model). The results of our RWR-Model are more reasonable and satisfactory than those of the baseline approaches.