Abstract: As the ASIC design cost becomes affordable only for very large-scale productions, the FPGA technology is currently becoming the leading technology for those applications that require a small-scale production. FPGAs can be considered as a technology crossing between hardware and software. Only a small-number of standards for the design of safety-critical systems give guidelines and recommendations that take the peculiarities of the FPGA technology into consideration. The main contribution of this paper is an overview of the existing design standards that regulate the design and verification of FPGA-based systems in safety-critical application fields. Moreover, the paper proposes a survey of significant published research proposals and existing industrial guidelines about the topic, and collects and reports about some lessons learned from industrial and research projects involving the use of FPGA devices.