Abstract: Over the past few years, wireless networking technologies have made vast forays in our daily lives. Inwireless ad-hoc networks, links are set up by a number of units without any permanent infrastructures. In this paper, the resource optimization is considered to maximize the network throughput by efficiently using the network capacity, where multi-hop functionality and spatial TDMA (STDMA) access scheme are used. The objective is to find the minimum frame length with given traffic distributions and corresponding routing information. Because of the complex structure of the underlying mathematical problem, previous work and analysis become intractable for networks of realistic sizes. The problem is addressed through mathematical programming approach, the linear integer formulation is developed for optimizing the network throughput, and then the similarity between the original problem and the graph edge coloring problem is shown through the conflict graph concept. A column generation solution is proposed and several enhancements are made in order to fasten its convergence. Numerical results demonstrate that the theoretical limit ofthe throughput can be efficiently computed for networks of realistic sizes.